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Combo-pilling is the newest fad or even better the newest into the future under scrutiny and therefore it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills has become popular will be the fact that by right now there are no long term prescription weightloss pills that have been licensed by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be approved by the FDA. Seizures certainly are a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug could also raise blood pressure levels and heartbeat, and shouldn't be used in those with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise hypertension and heart rate and must 't be used in patients with uncontrolled high blood pressure level, as well as by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients having a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients for the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking. "There were no signs and symptoms of depression or suicidal thoughts in trial participants," said Fujioka.